Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
[68Ga]Ga-THP-Pam
- Development stage
- Preclinical
- Lead developer
- King's College London
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
[68Ga]Ga-THP-Pam is a gallium-68 labeled bisphosphonate positron emission tomography (PET) radiotracer developed for imaging vascular calcification and bone-related conditions. It consists of the clinically used aminobisphosphonate pamidronate (Pam) conjugated to the rapid-chelating tris(hydroxypyridinone) (THP) ligand, which allows for simple, one-step, room-temperature radiolabeling with gallium-68. Unlike [18F]NaF, which is highly selective for hydroxyapatite (the main component of bone mineral), [68Ga]Ga-THP-Pam exhibits a broad affinity for various calcium minerals (such as whitlockite and other non-hydroxyapatite calcium salts) implicated in extraosseous and vascular calcification. This broad mineral affinity makes it a highly sensitive diagnostic agent for the early detection of vascular calcification and microcalcifications.
- Other names
- 68Ga-THP-Pam[68Ga]Ga-THP-pamidronategallium Ga-68 THP-pamidronategallium-68 THP-pamidronategallium68 THP-pamidronategallium 68 THP-pamidronate
Beyond the preview
Go deeper on [68Ga]Ga-THP-Pam.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on [68Ga]Ga-THP-Pam.